While butorphanol can be made from thebaine, it is usually manufactured synthetically. It was initially available in injectable formulations for human (Stadol®) and veterinary (Torbugesic® and Torbutrol®) use. Butorphanol is a morphinan-type synthetic opioid analgesic developed by Bristol-Myers.

This nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses pain.

This nasal spray comes as a solution (liquid) to spray in the nose. It is usually used as needed for pain, but not more often than once every 3 to 4 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

This nasal spray should relieve your pain soon after you use it. If you are using a low starting dose of butorphanol nasal spray, your doctor may tell you that you may use a second dose if you still have pain 60 to 90 minutes after your first dose. Do not use this second dose unless your doctor tells you that you may. Call your doctor if you still have pain after using the nasal spray as prescribed. Also, call your doctor if you have used the nasal spray for some time and find that it no longer works as well as it did at the beginning of your treatment.

Butorphanol nasal spray may be habit-forming. Use the nasal spray exactly as directed. Do not use a larger dose or use it more often or for a longer time than prescribed by your doctor. Call your doctor if you develop a strong desire to use more medication than prescribed.

Do not stop using butorphanol nasal spray without talking to your doctor. If you suddenly stop using butorphanol nasal spray, you may experience withdrawal symptoms such as nervousness, agitation, shakiness, diarrhea, chills, sweats, difficulty falling asleep or staying asleep, loss of coordination, confusion, or hallucinations (seeing things or hearing voices that do not exist).Your doctor will probably decrease your dose gradually.

Before you use butorphanol nasal spray for the first time, read the written directions provided by the manufacturer. Ask your doctor or pharmacist if you have any questions about how to use this nasal spray.

This brand is no longer on the market. Generic alternatives may be available.

Other Sources:

Butorphanol Injection

The injection is used to relieve moderate to severe pain. Butorphanol injection is also used to relieve pain during … pain and decrease awareness before or during surgery. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682667.html – Drugs and Supplements

Nasal Spray

The nasal spray is used to relieve moderate to severe pain.
https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601204.html – Drugs and Supplements

Your Pet’s Medications (American Veterinary Medical Association)

… be potent pain relievers. Examples include oxycodone, hydromorphone, butorphanol, meperidine, and fentanyl. Most of these drugs are …
https://www.avma.org/public/PetCare/Pages/YourPetsMedications.aspx – External Health Links

Opioid Use and Neural Tube Defects (Centers for Disease Control and Prevention)
… oxycodone, hydrocodone, morphine, propoxyphene, meperidine, methadone, tramadol, hydromorphone, butorphanol, heroin, fentanyl, buprenorphine, nalbuphine, and diphenoxylate. Making Treatment …

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